The second section of the museum is dedicated to Art Nouveau. A decorative style widespread throughout Europe and the United States between 1890 and the First World War, it presents characteristic peculiarities according to the nations where it developed. In this sense the Wolfsoniana offers an example of Italian Liberty by means of the partial reconstruction of a living room realized by the company Luigi Fontana & C in 1902. In this case the sinuous lines show the close relationship with the Art Nouveau of the Franco-Belgian.

The Italian examples are flanked by some international productions with particular attention paid to the Mittleuropa area, as is shown by the inlaid chest of drawers by Leopard Bauer and some office furniture by the Catalan Gaspar Homar. The sideboard by the Austrian Joseph Maria Olbrich and the study by the Hungarian Odon Farago and the Medusa glass door by Vetrate Artistiche G. Beltrami in Milan are works shown at the International Exposition of Modern Decorative Arts in Turin in 1902.